CONSTRUCTION OF DOXYCYLINE-DEPENDENT MINI-HIV-1 VARIANTS FOR THE DEVELOPMENT OF A VIROTHERAPY AGAINST LEUKEMIAS

Construction of doxycyline-dependent mini-HIV-1 variants for the development of a virotherapy against leukemias

Abstract T-cell acute lymphoblastic leukemia (T-ALL) is a high-risk type of blood-cell cancer.We describe the improvement of a candidate therapeutic virus for virotherapy of leukemic cells.Virotherapy is based on the exclusive replication of a virus in leukemic cells, leading to the selective removal of these malignant cells.To improve the safety o

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RNA interference of myocyte enhancer factor 2A accelerates atherosclerosis in apolipoprotein E-deficient mice.

Myocyte enhancer factor-2A (MEF 2A) has been shown to be involved in atherosclerotic lesion development, but its role in preexisting lesions is still unclear.In the present study we aim to assess the role of MEF 2A in the progression of pre-existing atherosclerosis.Eighty apolipoprotein E-deficient mice (APOE KO) were randomly allocated to control,

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