Construction of doxycyline-dependent mini-HIV-1 variants for the development of a virotherapy against leukemias
Abstract T-cell acute lymphoblastic leukemia (T-ALL) is a high-risk type of blood-cell cancer.We describe the improvement of a candidate therapeutic virus for virotherapy of leukemic cells.Virotherapy is based on the exclusive replication of a virus in leukemic cells, leading to the selective removal of these malignant cells.To improve the safety o